HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropyl Ether → N-(1,5-dimethylpyrazol-3-yl)-2,6 dimethyl benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropyl Ether | HCID 7914 | — |
| Reactant | 2,6-Dimethylbenzoyl chloride | HCID 89096 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 1,5-dimethyl-1H-pyrazol-3-amine | HCID 7017747 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | N-(1,5-dimethylpyrazol-3-yl)-2,6 dimethyl benzamide | HCID 11776550 | 38.2% |
Reaction Steps
To a cooled (0°-5° C.) solution of 3-amino-1,5-dimethyl pyrazole (95%, 32.7 g, 0.28M) in anhydrous CH2Cl2 (200 ml) was added a CH2Cl2 (100 ml) solution of the 2,6 dimethyl benzoyl chloride (23.6 g, 0.14M). The reaction mixture was allowed to room temperature for 18 hours and then CH2Cl2 was concentrated to give an oily mixture which was diluted in AcOEt. This suspension was then treated with saturated NaHCO3. After usual work-up, the crude material was cristallized with diisopropyloxide to give 13 g of the desired amide (38% : yield based on the 2,6-dimethyl benzoyl chloride).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05464860 |
| Source dataset | uspto-grants-1995_11 |
| ORD ID | ord-f98ffc91eb5e435fac5c17e51ecfdfc5 |
| Source note | uspto-grants-1995_11 |