Sodium Iodide → HCID 19375003, compound

Participants

Reaction Steps

To a cooled (0° C.) suspension of N-(1-methyl-5-benzyloxymethylpyrazol-3-yl)-2,6-dimethyl benzamide (9 g, 0.025M) and sodium iodide (19 g, 0.125M) in acetonitrile (250 ml) was added boron trifluoride etherate (18,3 g, 0,125M) in acetonitrile (60 ml) under nitrogen atmosphere. After being stirred for 2 hours at room temperature and usual work-up, the crude material was purified by column chromatography on silica gel using CH2Cl2, then CH2Cl2 /CH3OH=97.5/2.5 and 95/5 as eluents to give 1.5 g (23%) of a white solid.

Provenance & Evidence