Ammonia → HCID 86734042, compound

HRID 1287265Notes

Reaction equation

HRID 1287265 reaction equation
C[O:2][C:3](=O)[NH2:4].[CH2:6]([CH:8]1[CH2:12][CH2:11][CH2:10][CH:9]1[CH2:13][NH2:14])[CH3:7].N>O1CCOCC1>[CH2:6]([CH:8]1[CH2:12][CH2:11][CH2:10][CH:9]1[CH2:13][NH:14][C:3](=[O:2])[NH2:4])[CH3:7]

Participants

5

Reactant 3

HCID 222AmmoniaHCID 11722Methyl CarbamateHCID 22484520HCID 22484520, compound

Product 1

HCID 86734042HCID 86734042, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

4.33 g of N-[4-(β-<3-methoxy-5-chlorothiophene-2-carboxamido>-ethyl)-benzenesulfonyl]-carbamic acid methyl ester (melting point 186° - 188° C) were dissolved in 100 ml of dioxane and, after addition of 1.2 g of 2-ethyl-cyclopentylmethylamine, kept for 2 hours under reflux. The clear solution was poured into dilute aqueous ammonia solution, filtered and acidified with 2N-hydrochloric acid. The N-[4-(β-<3-methoxy-5-chlorothiophene-2-carboxamido>-ethyl)-benzenesulfonyl]-N'-(2-ethyl-cyclopentyl-methyl)-urea so obtained was found to melt at 160° - 161° C after recrystallization from methanol.

Workup

  1. temperatureunder reflux
  2. filtrationfiltered

Sources & evidence

ORD record
ord-07f1c6d11d1749b5928bd325deaa4a1f
Source dataset
uspto-grants-1976_10
Patent number
US03984416

Reaction notes

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