Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Methyl isothiocyanate | HCID 11167 | — |
| Reactant | HCID 86734043 | HCID 86734043 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 21507673 | HCID 21507673 | — |
Reaction Steps
A solution of Nε-benzoyl-L-lysine methyl ester (26 g) and methyl isothiocyanate (6.75 g) in ethanol (250) was heated under reflux for 12 hours. The solution was saturated with ammonia at 0°C and heated in a bomb at 40°C for 3 days. Evaporation of the solvent gave a gum which was crystallised from isopropyl alcohol. Recrystallisation from iso-propyl alcohol gave the title compound as the quarter isopropyl alcohol solvate 10 g (m.p. 137-8°C). Found: C, 59.4; H, 6.25; N, 13.1. C15H19N3O2S.1/4C3H8O requires C, 59.0; H, 6.6; N, 13.1%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US03984430 |
|---|
| Source dataset | uspto-grants-1976_10 |
|---|
| ORD ID | ord-b972f7ff50fd425d80243ada77c552b5 |
|---|
| Source note | uspto-grants-1976_10 |
|---|
