反应详情

A solution of 2-methyl-2,3-methylene-6-(1-cyclopropylethoxy)carbonylaminopenam-3-carboxylic acid(840 mg.) in formic acid(5 ml.) was stirred for 1.5 hours at room temperature. After the reaction, formic acid was distilled off under reduced pressure. The residue was washed with ether, crystallized by adding acetonitrile containing water and the crystals were collected by filtration to give 2-methyl-2,3-methylene-6-aminopenam-3-carboxylic acid(380 mg.), mp. 200°C (dec.).

1. distillationwas distilled off under reduced pressure
2. washThe residue was washed with ether
3. customcrystallized
4. additionby adding acetonitrile
5. additioncontaining water
6. filtrationthe crystals were collected by filtration