HCID 68135748, compound → HCID 68132250, compound

Participants

Reaction Steps

A solution of 2-methyl-2,3-methylene-6-[N-(1-cyclopropylethoxy) carbonyl-2-phenylglycyl]aminopenam-3-carboxylic acid (1.88 g.) in formic acid (10 ml.) was stirred for 1 hour at room temperature and the solvent was distilled off under reduced pressure at room temperature. The residue was pulverized by adding ether and fitered. The powder was added to a mixture of acetonitrile (10 ml.) and water (1 ml.) and precipitated crystals were collected by filtration, washed with acetonitrile and dried to give 2-methyl-2,3-methylene-6-(2-phenylglycyl)aminopenam-3-carboxylic acid (0.89 g.), mp 200° to 202°C (dec.).

Provenance & Evidence