Potassium Hydroxide → HCID 68132000, compound

Participants

Reaction Steps

To a solution of 2-methyl-2,3-methylene-6-(2-phenyl-2-formyloxyacetamido)penam-3-carboxylic acid (1.1 g.) in methanol (10 ml.) and water (7 ml.) was added dropwise 1N-potassium hydroxide aqueous solution adjusting to pH 7 to 8, and the mixture was stirred for 10 minutes at room temperature. After the reaction was completed, methanol was distilled off from the reaction mixture under reduced pressure. The residual solution was acidified by adding 1N-hydrochloric acid and extracted with ethyl acetate. The solvent was distilled off from the extract under reduced pressure and the residue was pulverized by n-hexane to give 2-methyl-2,3-methylene-6-(2-phenyl-2-hydroxyacetamido)penam-3-carboxylic acid (0.4 g.).

Provenance & Evidence