HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Hydroxy-3,5-bis(isopropyl)benzaldehyde → 5-[[4-Hydroxy-3,5-bis(1-methylethyl)phenyl]methylene]-2-thioxo-4-imidazolidinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Hydroxy-3,5-bis(isopropyl)benzaldehyde | HCID 82712 | — |
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | 2-Thiohydantoin | HCID 1274030 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 5-[[4-Hydroxy-3,5-bis(1-methylethyl)phenyl]methylene]-2-thioxo-4-imidazolidinone | HCID 53946215 | 32.9% |
Reaction Steps
Prepared according to the procedure described in Example 1 using 4-hydroxy-3,5-bis(1-methylethyl)benzaldehyde (3.0 g, 15 mmoles), 2-thiohydantoin (1.6 g, 14 mmoles), sodium acetate (4.2 g, 51 mmoles), and acetic acid (35 ml), filtered off, dried, and recrystallized from acetonitrile to afford the pure product (1.4 g), mp 225°-230° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05464856 |
| Source dataset | uspto-grants-1995_11 |
| ORD ID | ord-94182eba54ee4fcc8316740632dfd6a6 |
| Source note | uspto-grants-1995_11 |