HCID 68132557, compound → HCID 68131570, compound

HRID 1287334Notes

Reaction equation

HRID 1287334 reaction equation
[CH3:1][C:2]12[CH2:15][C:6]1([C:7]([O:9]CC(Cl)(Cl)Cl)=[O:8])[N:5]1[C:16](=[O:32])[CH:17]([NH:18][S:19]([C:22]3[CH:27]=[CH:26][C:25]([NH:28][C:29](=[O:31])[CH3:30])=[CH:24][CH:23]=3)(=[O:21])=[O:20])[C@H:4]1[S:3]2>[Zn].C(O)(=O)C>[CH3:1][C:2]12[CH2:15][C:6]1([C:7]([OH:9])=[O:8])[N:5]1[C:16](=[O:32])[CH:17]([NH:18][S:19]([C:22]3[CH:27]=[CH:26][C:25]([NH:28][C:29](=[O:31])[CH3:30])=[CH:24][CH:23]=3)(=[O:20])=[O:21])[C@H:4]1[S:3]2

Participants

4

Reactant 1

HCID 68132557HCID 68132557, compound

Product 1

HCID 68131570HCID 68131570, compoundYield 60.5%

Reagents, catalysts & solvents 2

HCID 23994ZincCatalystHCID 176Acetic AcidSolvent

Procedure

2,2,2-Trichloroethyl 2-methyl-2,3-methylene-6-(4-acetamidobenzenesulfonamido)penam-3-carboxylate (1.09 g.), acetic acid (1.5 ml.) and zinc powder (1.2 g.) were treated in the similar manner as described in Example 1 and the residue was crystallized using ethyl acetate to give 2-methyl-2,3-methylene-6-(4-acetamidobenzenesulfonamido)penam-3-carboxylic acid (0.5 g.), mp. 230°C (dec.).

Workup

  1. customthe residue was crystallized

Sources & evidence

ORD record
ord-453e57da0a7f4c02ab1401c258ec7ac3
Source dataset
uspto-grants-1976_10
Patent number
US03984397

Reaction notes

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