1-(Phenylmethyl) butanedioate → Beta-carbobenzyloxypropionic acid anhydride

Participants

Reaction Steps

To 179 grams of beta-carbobenzyloxypropionic acid (IV) there are added 500 ml of acetic anhydride and the solution is heated on a boiling water bath for 45 minutes. The excess reactant is distilled off and the residue is crystallized from one liter of carbon tetrachloride, the result being 140 grams (81% of theory) of (VI), which has a melting point of 70°C-71°C.

Provenance & Evidence