Water → HCID 20322157, compound

HRID 1287357Notes

Reaction equation

HRID 1287357 reaction equation
Cl[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][CH2:10][CH2:11][Cl:12].[C:13]([O-:16])(=[O:15])[CH3:14].[Na+].O>C(O)(=O)C>[Cl:12][CH2:11][CH2:10][CH2:9][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=1[CH2:2][O:16][C:13](=[O:15])[CH3:14]

Participants

5

Reactant 3

HCID 962WaterHCID 517045Sodium AcetateHCID 123739901-(Chloromethyl)-2-(3-chloropropyl)benzene

Product 1

HCID 20322157HCID 20322157, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

70 g (345 mmols) of 3-(2-Chloromethylphenyl)-propyl chloride (JACS 75, 2053 (1953)) and 50 g (0.61 mmol) of sodium acetate were heated to the boiling point while stirring in 250 ml of glacial acetic acid. It resulted from the thin layer chromatography that the reaction was finished after 41/2 hours. After cooling about 700 ml of water were added and the product was extracted with benzene. The organic phase was washed with water, dried and distilled off after evaporation of the solvent.

Workup

  1. customIt resulted from the thin layer chromatography that the reaction
  2. custom2 hours
  3. additionwere added
  4. extractionthe product was extracted with benzene
  5. washThe organic phase was washed with water
  6. customdried
  7. distillationdistilled off
  8. customafter evaporation of the solvent

Sources & evidence

ORD record
ord-ef7720a1dc5e4cf2900ce3ad6fe94177
Source dataset
uspto-grants-1976_10
Patent number
US03984459

Reaction notes

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