反应详情

With exclusion of humidity 12.5 g (0.25 mol) of dry NaCN were heated in 65 ml of anhydrous DMSO to 90°C and at this temperature 44.8 g (0.2 mol) of acetic acid-2-(3-chloropropyl)-benzyl ester were added dropwise. Then the mixture was heated for 50 minutes to 120°C and distributed after cooling between water and ether. The aqueous phase was extracted three times with ether, the organic phase was washed three times with a saturated sodium chloride solution, dried and concentrated under reduced pressure. The product boiled at 128°C/0.2 mm mercury.

1. additionwere added dropwise
2. temperatureThen the mixture was heated for 50 minutes to 120°C
3. extractionThe aqueous phase was extracted three times with ether
4. washthe organic phase was washed three times with a saturated sodium chloride solution
5. customdried
6. concentrationconcentrated under reduced pressure