Sodium Hydroxide → HCID 152746712, compound

Participants

Reaction Steps

A solution of 30 g. of 1-(4-nitrophenyl)-3-(pentanimidoyl)urea hydrochloride (see Example 9) in 300 ml. ice-cold water was treated with 8 g. sodium hydroxide in 40 ml. water. The mixture was extracted with ether and the ethereal solution was dried over calcium sulfate and evaporated to dryness. The residue was taken up in 400 ml. absolute alcohol and hydrogenated over Raney nickel at 392 pounds pressure and at room temperature until the hydrogen uptake was complete. The catalyst was removed by filtration and the solvent was removed under reduced pressure at 50°C. to give after recrystallization successively from ether and benzene 13.5 g. of 1-(4-aminophenyl)-3-(pentanimidoyl)urea; m.p. 102°-103°C.

Provenance & Evidence