Acetamidine monohydrochloride → N-[[(3-Chloro-4-cyanophenyl)amino]carbonyl]ethanimidamide

Participants

Reaction Steps

Following a procedure similar to that described in Example 1 but using 2.06 g. sodium in 250 ml. dry acetone, 9.2 g. acetamidine hydrochloride and 16 g. 3-chloro-4-cyanophenyl isocyanate in 250 ml. dry acetone, there was obtained after filtration of the reaction mixture a solid which on washing with water and recrystallization from methyl alcohol gave 1-(3-chloro-4-cyanophenyl)3 -(acetimidoyl)urea; m.p.182°-183°C.

Provenance & Evidence