HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetone → HCID 178444022, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetone | HCID 180 | — |
| Reactant | 2-Chloro-5-trifluoromethylphenyl isothiocyanate | HCID 141005 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | Heptanimidamide hydrochloride | HCID 14144282 | — |
| Solvent | Benzene hexane | HCID 110624 | — |
| Product | HCID 178444022 | HCID 178444022 | — |
Reaction Steps
Following a procedure similar to that described in Example 42 but using 1.86 g. sodium in 250 ml. dry acetone, 13.4 g. heptanamidine hydrochloride, and 19.2 g. 2-chloro-5-(trifluoromethyl)phenyl isothiocyanate [prepared from 2-chloro-5-(trifluoromethyl)aniline] in 70 ml. acetone there was obtained 1-[2-chloro-5-(trifluoromethyl)phenyl]-3-(heptanimidoyl)-2-thiourea, m.p. 88°-90°C. (from benzene-n-hexane); hydrochloride (10.3 g.), m.p. 160°-161°C. (from acetonitrile).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03984467 |
| Source dataset | uspto-grants-1976_10 |
| ORD ID | ord-5ff1e34663a94de3b26991ae5a7821f4 |
| Source note | uspto-grants-1976_10 |