Aluminum(III) Chloride → 2-Ethyl-2-n-propyl-5-hydroxy-6,7-dichloro-1-indanone

HRID 1287431Notes

Reaction equation

HRID 1287431 reaction equation
[CH2:1]([C:3]1([CH2:17][CH2:18][CH3:19])[CH2:11][C:10]2[C:5](=[C:6]([Cl:15])[C:7]([Cl:14])=[C:8]([O:12]C)[CH:9]=2)[C:4]1=[O:16])[CH3:2].[Cl-].[Al+3].[Cl-].[Cl-]>CCCCCCC>[CH2:1]([C:3]1([CH2:17][CH2:18][CH3:19])[CH2:11][C:10]2[C:5](=[C:6]([Cl:15])[C:7]([Cl:14])=[C:8]([OH:12])[CH:9]=2)[C:4]1=[O:16])[CH3:2]

Participants

4

Reactant 2

HCID 6451240Aluminum(III) ChlorideHCID 123955632-Ethyl-2-n-propyl-5-methoxy-6,7-dichloro-1-indanone

Product 1

HCID 123955852-Ethyl-2-n-propyl-5-hydroxy-6,7-dichloro-1-indanone

Reagents, catalysts & solvents 1

HCID 8900HeptaneSolvent

Procedure

2-Ethyl-2-n-propyl-5-hydroxy-6,7-dichloro-1-indanone is prepared following substantially the same procedure described in Example 5, Step F, using the following substances: 2-ethyl-2-n-propyl-5methoxy-6,7-dichloro-1-indanone (11 g., .037 mole), aluminum chloride (12.5 g., 0.094 mole) and heptane (400 ml.). The above procedure gives 9.0 g. of 2-ethyl-2-n-propyl-5-hydroxy-6,7-dichloro-1-indanone which after recrystallization from methylcyclohexane melts at 153° C.

Workup

  1. customThe above procedure gives 9.0 g
  2. customof 2-ethyl-2-n-propyl-5-hydroxy-6,7-dichloro-1-indanone which after recrystallization from methylcyclohexane melts at 153° C.

Sources & evidence

ORD record
ord-e547fd68ad11444398be7a4eb2593db1
Source dataset
uspto-grants-1976_10
Patent number
US03984465

Reaction notes

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