1-(2-Chloroethyl)piperidine → HCID 21508882, compound

HRID 1287493Notes

Reaction equation

HRID 1287493 reaction equation
[CH3:1][O:2][C:3]1[C:8]2[O:9][C:10](=[O:17])[C:11]3[CH2:12][NH:13][CH2:14][CH2:15][C:16]=3[C:7]=2[CH:6]=[CH:5][C:4]=1[O:18][CH3:19].Cl[CH2:21][CH2:22][N:23]1[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]1>>[CH3:1][O:2][C:3]1[C:8]2[O:9][C:10](=[O:17])[C:11]3[CH2:12][N:13]([CH2:21][CH2:22][N:23]4[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]4)[CH2:14][CH2:15][C:16]=3[C:7]=2[CH:6]=[CH:5][C:4]=1[O:18][CH3:19]

Participants

3

Reactant 2

HCID 748271-(2-Chloroethyl)piperidineHCID 13136911HCID 13136911, compound

Product 1

HCID 21508882HCID 21508882, compound

Procedure

In the same way as described in Example 5, 5.7 mmoles of 1,2,3,4-tetrahydro-7,8-dimethoxy-5H-[1]benzopyrano[3,4-c]pyridin-5-one was alkylated with N-(2-chloroethyl)-piperidine to give, after recrystallization from MeOH, 0.5 g of product; mp 236°-239°C.

Workup

  1. customto give
  2. customafter recrystallization from MeOH, 0.5 g of product

Sources & evidence

ORD record
ord-c75a9fd4c1834a00be1b93167803e4af
Source dataset
uspto-grants-1976_10
Patent number
US03984546

Reaction notes

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