Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Benzene, 1-(chloromethyl)-2-fluoro- | HCID 9580 | — |
| Reactant | Glutathione | HCID 124886 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 68145616 | HCID 68145616 | — |
Reaction Steps
A mixture of 3.07 g of glutathione, 2.8 cc of triethylamine and 100 cc of methanol is brought to a boil. Then a solution of 1.45 g of o-fluorobenzyl chloride in 20 cc of methanol is added. After this addition, the resulting mixture is heated for 3 hours at 50°C, then allowed to cool and, by addition of dilute hydrochloric acid, 3.35 g of a white product are precipitated which can then be crystallized in water. Thus a product having a melting point of around 200°C (with decomposition) is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US03984569 |
|---|
| Source dataset | uspto-grants-1976_10 |
|---|
| ORD ID | ord-3423ed228b774f2c9ff316b9c606a223 |
|---|
| Source note | uspto-grants-1976_10 |
|---|
