Aziridine → HCID 88844931, compound

HRID 1287539Notes

Reaction equation

HRID 1287539 reaction equation
[CH2:1]1[NH:3][CH2:2]1.[NH2:4][C@@H:5]([CH2:9][CH2:10][C:11]([NH:13][C@H:14]([C:17]([NH:19][CH2:20][C:21]([OH:23])=[O:22])=[O:18])[CH2:15][SH:16])=[O:12])[C:6]([OH:8])=[O:7]>O>[NH2:3][CH2:2][CH2:1][S:16][CH2:15][C@@H:14]([C:17]([NH:19][CH2:20][C:21]([OH:23])=[O:22])=[O:18])[NH:13][C:11](=[O:12])[CH2:10][CH2:9][C@@H:5]([C:6]([OH:8])=[O:7])[NH2:4]

Participants

4

Reactant 2

HCID 9033AziridineHCID 124886Glutathione

Product 1

HCID 88844931HCID 88844931, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

There are added over a 5 minute period 1.29 g of ethylene imine, freshly distilled, to a solution of 30 millimoles of glutathione in 150 cc of water. The resulting mixture is stirred for ten minutes at ambient temperature and then concentrated to dryness. The resulting solid residue is triturated and washed successively with benzene, ethanol and acetone. The white product thus obtained (9.5 g) melts around 200° with decomposition.

Workup

  1. concentrationconcentrated to dryness
  2. customThe resulting solid residue is triturated
  3. washwashed successively with benzene, ethanol and acetone
  4. customThe white product thus obtained (9.5 g)
  5. custommelts around 200° with decomposition

Sources & evidence

ORD record
ord-eb84c3007e8848bb9d0a5625f14e2e5e
Source dataset
uspto-grants-1976_10
Patent number
US03984569

Reaction notes

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