HCID 21509155, compound → HCID 54390534, compound

HRID 1287540Notes

Reaction equation

HRID 1287540 reaction equation
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[N:13]([C:14](=[O:22])[CH2:15][CH2:16][N:17]3[CH2:21][CH2:20][CH2:19][CH2:18]3)[CH2:12][CH:11]3[CH2:23][CH2:24][CH2:25][N:10]3[CH2:9][C:8]=2[CH:26]=1)([O-])=O.[H][H]>[Pd].C(O)C>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]2[N:13]([C:14](=[O:22])[CH2:15][CH2:16][N:17]3[CH2:18][CH2:19][CH2:20][CH2:21]3)[CH2:12][CH:11]3[CH2:23][CH2:24][CH2:25][N:10]3[CH2:9][C:8]=2[CH:26]=1

Participants

5

Reactant 2

HCID 21509155HCID 21509155, compoundHCID 178418361HCID 178418361, compound2×

Product 1

HCID 54390534HCID 54390534, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of 5 g. of 2,3,5,10,11,11a-hexahydro-7-nitro-10-[3-(1-pyrrolidinyl)propionyl]-1H-pyrrolo[2,1-c][1,4]benzodiazepine, 250 ml. of ethanol and 2 g. of 10% palladium on carbon catalyst is shaken under about 3 atmospheres of hydrogen pressure in a Parr hydrogenerator until hydrogen uptake is complete. The catalyst is filtered off and the mother liquor is concentrated to obtain the 7-amino-2,3,5,10,11,11a-hexahydro-10-[3-(1-pyrrolidinyl)propionyl]-1H-pyrrolo[2,1-c] [1,4]benzodiazepine.

Workup

  1. additionA mixture of 5 g
  2. filtrationThe catalyst is filtered off
  3. concentrationthe mother liquor is concentrated

Sources & evidence

ORD record
ord-b35aa33099004a10a0c63db04ffb5300
Source dataset
uspto-grants-1976_10
Patent number
US03984562

Reaction notes

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