反应详情

To a clean dry 250 ml. round bottom 3-neck flask equipped with a magnetic stirrer, thermometer and addition funnel was added 6.69 g. (0.02 mole) of 3,5-di-t-butyl-4-hydroxy -benzylpyridinium chloride in 100 ml. of ethanol and 2.36 g. (0.022 mole) of nitrosobenzene. The clear solution was cooled to 0° to 5° C. and sodium hydroxide (2.45 g.; 0.06 mole) in 60 ml. of water was added dropwise in 40 minutes. The reaction mixture was stirred an additional 3 hours at ambient temperature and then diluted with 50 ml. water, filtered, and the collected product dried to yield 5.07 g. (79.2% yield) of 1-(3,5-di-t-butyl-4-hydroxyphenyl)-N-phenyl-nitrone, MP-137°-140° C.

1. customTo a clean dry 250 ml
2. customround bottom 3-neck flask equipped with a magnetic stirrer
3. additionthermometer and addition funnel
4. additionwas added 6.69 g
5. temperatureThe clear solution was cooled to 0° to 5° C.
6. additiondiluted with 50 ml
7. filtrationwater, filtered
8. customthe collected product dried
9. customto yield 5.07 g