反应详情

A mixture of 7.4 mmol of L-valine, 10 ml of dimethyl sulfoxide and 23 mmol of sym-trichlorotrifluoroacetone was stirred at room temperature for 24 hours in a flask protected from atmospheric moisture. A complete solution was obtained within the first hour. The progress of the reaction was followed by taking samples periodically and submitting them to gas-liquid chromatographic analysis. The reaction mixture was poured into 50 ml of ice water and the resultant mixture was extracted thrice with n-butanol and chromatographed on a column packed with silica gel. N-trifluoroacetylvaline, melting at 88°-89° C., was obtained in a yield of 94 percent.

1. customA complete solution was obtained within the first hour
2. extractionthe resultant mixture was extracted thrice with n-butanol
3. customchromatographed on a column