反应详情

A mixture of 7.85 mmol of glycylglycine, 15 ml of dimethyl sulfoxide and 24 mmol of sym-trichlorotrifluoroacetone was stirred at room temperature for 24 hours in a flask protected from atmospheric moisture. The reaction mixture was then poured into 50 ml of ice water and the resultant mixture was extracted thrice with n-butanol and chromatographed on a column packed with silica gel. N-trifluoroacetylglycylglycine, melting at 184.7°-185.0° C., was obtained in a yield of 42.5 percent.

1. extractionthe resultant mixture was extracted thrice with n-butanol
2. customchromatographed on a column