(+-)-Aspartic Acid → Dipotassium 2-aminobutanedioate
Reaction equation
[OH-].[K+:2].[NH2:3][CH:4]([C:9]([OH:11])=[O:10])[CH2:5][C:6]([OH:8])=[O:7].C(O)C>O>[NH2:3][CH:4]([C:9]([O-:11])=[O:10])[CH2:5][C:6]([O-:8])=[O:7].[K+:2].[K+:2]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
Potassium hydroxide 11.3 g was added to a suspension of 13.3 g DL-aspartic acid in a mixed solvent of 60 ml ethyl alcohol and 60 ml water to form a solution of dipotassium DL-aspartate. To the ice-cooled resultant solution a solution of lauric acid-sulfuric acid mixed acid anhydride and 10 ml of 10 N potassium hydroxide was added dropwise simultaneously with stirring. While the pH was controlled to 12 stirring at room temperature was then continued for 1 hour. The reaction mixture was treated in the similar manner as in Example 3 to obtain 14.3 g crude crystals of N-lauroyl-DL-aspartic acid.
Sources & evidence
- ORD record
- ord-4289861683aa48dd950c36c7b720f644
- Source dataset
- uspto-grants-1976_10
- Patent number
- US03985722
Reaction notes
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