Methanol → Lauroyl Glutamic Acid

Participants

Reaction Steps

L-Glutamic acid 2.9 g was dissolved in 30 ml water and 30 ml methanol and 1.6 g of sodium hydroxide. To this solution was added 8.8 g of the crystal of palmitic acid sulfuric acid mixed anhydride and 10 N sodium hydroxide to keep pH 12 to 13, with stirring at 21° - 22°C. The reaction mixture was stirred for an additional 1 hour, and then treated by the same manner as in Example 1. N-Lauroyl-L-glutamic acid was obtained. Yield 6.4 g (96.9%). M.P. 101° - 104.5°C.

Provenance & Evidence