HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 10-methyl-2,3-dihydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H,11aH)-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | N-Methylisatoic anhydride | HCID 25160 | — |
| Reactant | L-Proline | HCID 145742 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 10-methyl-2,3-dihydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H,11aH)-dione | HCID 9859436 | — |
Reaction Steps
The N-methyl isatoic anhydride (I) and L-proline (II) are reacted in a solvent such as ethanol or dimethyl sulfoxide at 25° to 200° C. for a period of 1 to 24 hours to produce the dextrorotatory isomer of the 1,2,3,11a-tetrahydro-10-methyl-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5,11(10H)-dione.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03985732 |
| Source dataset | uspto-grants-1976_10 |
| ORD ID | ord-734de9473da94631982cf5506512a24d |
| Source note | uspto-grants-1976_10 |