Hydrogen Bromide → HCID 12318595, compound

Participants

Reaction Steps

A solution of 4 parts of 10-(aminomethyl)-N,N,5-triethyl-10,11-dihydro-5H-dibenz[b,f]azepine-10-ethanamine in a minimal quantity of absolute ethanol is acidified with a 15% solution of hydrogen bromide in ethanol. Sufficient anhydrous ether is then added to induce separation of an oil. Supernatant solvents are decanted from the oil, which is crystallized by slurrying with anhydrous ether. The product thus isolated, filtered off and recrystallized from a mixture of ethanol and absolute ether, affords 10-(aminomethyl)-N,N,5-triethyl-10,11-dihydro-5H-dibenz[b,f]azepine-10-ethanamine dihydrobromide as a colorless solid which, dried in vacuo at 80°, melts at 234°- 236°.

Provenance & Evidence