Hydrogen Bromide → HCID 12318597, compound

Participants

Reaction Steps

A solution of 4 parts of 10-(aminomethyl)-5-ethyl-10,11-dihydro-N,N-diisopropyl-5H-dibenz[b,f]azepine-10-ethanamine in a minimal amount of absolute ethanol at around 20° is acidified with a 15% solution of hydrogen bromide in ethanol. Sufficient ether is added to cause an oil to separate. Supernatant solvents are decanted from the oil, which is crystallized by slurrying with anhydrous ether. Recrystallization from absolute ethanol affords 10-(aminomethyl)-5-ethyl-10,11-dihydro-N,N-diisopropyl-5H-dibenz[b,f]azepine-10-ethanamine dihydrobromide as a colorless solid which, washed with anhydrous ether and dried in vacuo at 80°, melts at approximately 239°-240°.

Provenance & Evidence