Methanol → HCID 131710482, compound

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Reaction Steps

7-Cyanomethylthioacetamido-3-methoxy-3-cephem-4-carboxylic acid (35 mg.) is dissolved in 1 ml. of methanol and 50 μ l of 2.5 M potassium 2-ethyl hexanoate is added. Addition of ether causes precipitation of a very hygroscopic solid. All solvent is removed in vacuo from the mixture and the residue is solidified by the addition of acetonitrile. The desired potassium salt is collected by filtration and dried yielding 19 mg; NMR (DMSO d6 δ) 3.43 (m, CH2),3.52 (s, NCCH2SCH2CO--) 3.76 (s,OCH3), 4.10 (d, J=4Hz, H6), 5.30 (q, J=4, 9.5 Hz, H7), 9.03 (d, J=9.5 Hz,NH); νmax (KBr) 3575, 3270, 2240, 1750, 1630, 1595, 1540 cm-1.

Provenance & Evidence