Dodecanoyl chloride → HCID 21505568, compound

Participants

Reaction Steps

In accordance with the procedure described in the foregoing Examples, 12.96 grams of 8-methoxy-10-[4-(3-hydroxypropyl)piperazino]-10,11-dihydrodibenzo[b,f]thiepin was reacted with 13.1 grams of lauroyl chloride (dodecanoyl chloride) in 50 milliliters of benzene and the resulting crude 8-methoxy-10-[4-(3-dodecanoyloxypropyl)piperazino]-10,11-dihydrodibenzo[b,f]thiepin was purified by recrystallization of the maleate from acetone and recovered in the form of its di(hydrogen maleate). The salt was recovered in a yield of 14.9 grams and had a melting point of 126-129°C. The pure ester was recovered in the form of a viscous oil by adding the salt to a dilute aqueous ammonium hydroxide solution and extracting the resulting solution with benzene. EXAMPLE 4

Provenance & Evidence