Octanoyl chloride → HCID 21505558, compound

Participants

Reaction Conditions

Reaction Steps

In accordance with the general procedure described in the foregoing Examples, 14.0 grams of 8-methylthio-10-[4-(3-hydroxypropyl)piperazino]-10,11-dihydrodibenzo[b,f]thiepin was reacted with 12.2 grams of caprylyl chloride (octanoyl chloride) in a mixture of 20 milliliters of chloroform and 60 milliliters of benzene. After the reaction mixture had been allowed to stand for 4 days at room temperature, the reaction mixture was heated to a temperature of 60°C and further treated as described in the preceding Example. The recovered crude 8-methylthio-10-[4-(3-octanoyloxypropyl)piperazino]-10,11-dihydrodibenzo[b,f]thiepin was thereafter converted into the crystalline di(hydrogen maleate) as described in the foregoing Example. The salt was recovered in a yield of 13.7 grams and, after recrystallization from acetone, had a melting point of 122°-123°C. The pure base was recovered in the form of a viscous oil by treatment of the pure salt with a dilute aqueous solution of ammonium hydroxide as described in the foregoing Example.

Provenance & Evidence