Dodecanoyl chloride → HCID 21505557, compound

Participants

Reaction Steps

In accordance with the general method described in the foregoing Examples, 10.15 grams of 8-ethyl-10-[4-(3-hydroxypropyl)piperazino]-10,11-dihydrodibenzo[b,f]thiepin was reacted with a solution of 12.5 grams of lauroyl chloride (dodecanoyl chloride) in a mixture of 60 milliliters of benzene and 20 milliliters of chloroform. By adding a solution of 6.15 grams of maleic acid in 60 milliliters of acetone to the crude product, 14.0 grams of 8-ethyl-10-[4-(3-dodecanoyloxypropyl)piperazino]-10,11-dihydrodibenzo[b,f]thiepin di(hydrogen maleate) was recovered. The salt, after recrystallization from acetone, had a melting point of 126°-128°C. Its elemental analysis corresponded to the empirical formula C43H60N2O10S. The free base was obtained in the form of a colorless very viscous oil which was very soluble in vegetable oils by dissolving the salt in a dilute aqueous ammonium hydroxide solution and extracting the resulting solution with benzene.

Provenance & Evidence