Octanoyl chloride → HCID 21505572, compound

Participants

Reaction Steps

In accordance with the general procedure described in the foregoing Examples, 4.1 grams of 8-(n-butyl)-10-[4-(3-hydroxypropyl)piperazino]-10,11-dihydrodibenzo[b,f]thiepin was reacted with 3.2 grams of caprylyl chloride (octanoyl chloride) in a mixture of 18 milliliters of benzene and 7 milliliters of chloroform. A solution of 2.3 grams of maleic acid in 25 milliliters of acetone was then added to the mixture and the resulting 8-(n-butyl)-10-[4-(3-oxtanoyloxypropyl)piperazino]-10,11-dihydrodibenzo[b,f]thiepin di(hydrogen maleate) which had a melting point of 113°-115°C, after recrystallization from acetone, was recovered. Its elemental analysis corresponded to the empirical formula C41H56N2O10S. The free base was obtained in the form of a colorless very viscous oil which was very soluble in vegetable oils by dissolving the salt in a dilute aqueous ammonium hydroxide solution and extracting the solution with benzene.

Provenance & Evidence