Methanol → HCID 21505598, compound

HRID 1287636Notes

Reaction equation

HRID 1287636 reaction equation
[Cl-].[F:2][C:3]1[CH:25]=[CH:24][C:6]([C:7]([CH2:9][CH2:10][CH2:11][N+:12]2[CH:17]=[CH:16][C:15]([C:18]3[S:19][CH:20]=[C:21]([CH3:23])[N:22]=3)=[CH:14][CH:13]=2)=[O:8])=[CH:5][CH:4]=1.CO.[BH4-].[Na+]>O>[F:2][C:3]1[CH:25]=[CH:24][C:6]([CH:7]([OH:8])[CH2:9][CH2:10][CH2:11][N:12]2[CH2:13][CH:14]=[C:15]([C:18]3[S:19][CH:20]=[C:21]([CH3:23])[N:22]=3)[CH2:16][CH2:17]2)=[CH:5][CH:4]=1

Participants

5

Reactant 3

HCID 887MethanolHCID 4311764Sodium borohydrideHCID 68130838HCID 68130838, compound

Product 1

HCID 21505598HCID 21505598, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a 0.4 g. portion of 1-(3-p-fluorobenzoylpropyl)- 4-(4-methyl-2-thiazolyl)pyridinium chloride, prepared as described in Example 4, in 20 ml. of methanol is added portionwise with stirring 0.4 g. of sodium borohydride. The mixture is stirred for 2 hours and then poured into water causing the formation of white solid which is separated and recrystallized from acetone and water, m.p. 89°-90.5° C.

Workup

  1. stirringThe mixture is stirred for 2 hours
  2. customis separated
  3. customrecrystallized from acetone and water, m.p. 89°-90.5° C.

Sources & evidence

ORD record
ord-7ca609a056534258a41d74d1998529b2
Source dataset
uspto-grants-1976_10
Patent number
US03985754

Reaction notes

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