Sodium borohydride → HCID 178435534, compound

HRID 1287637Notes

Reaction equation

HRID 1287637 reaction equation
Cl([O-])(=O)(=O)=O.[CH2:6]([C:8]1[CH:12]=[C:11]([C:13]2[CH:18]=[CH:17][N+:16]([CH2:19][CH2:20][CH2:21][C:22](=[O:30])[C:23]3[CH:28]=[CH:27][C:26]([F:29])=[CH:25][CH:24]=3)=[CH:15][CH:14]=2)[NH:10][N:9]=1)[CH3:7].[BH4-].[Na+]>CO>[CH2:6]([C:8]1[CH:12]=[C:11]([C:13]2[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][CH2:21][CH:22]([C:23]3[CH:28]=[CH:27][C:26]([F:29])=[CH:25][CH:24]=3)[OH:30])[CH2:15][CH:14]=2)[NH:10][N:9]=1)[CH3:7]

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 178435535HCID 178435535, compound

Product 1

HCID 178435534HCID 178435534, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a 2.2 g. portion of 4-(3-ethyl-5-pyrazolyl)-1 -(3-p-fluorobenzoylpropyl)pyridinium perchlorate, prepared as described in Example 2, in 100 ml. of methanol is added portionwise with stirring 2.2 g. of sodium borohydride. The mixture is stirred for 2 hours and then poured into ice water causing formation of a white solid which was collected and recrystallized from methanol, m.p. 140.5°-141.5° C.

Workup

  1. stirringThe mixture is stirred for 2 hours
  2. customwas collected
  3. customrecrystallized from methanol, m.p. 140.5°-141.5° C.

Sources & evidence

ORD record
ord-1362821b2e1240cc8ceebe6359364bb0
Source dataset
uspto-grants-1976_10
Patent number
US03985754

Reaction notes

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