4-Chlorobutyrophenone → HCID 21505615, compound

Participants

Reaction Steps

To a 4.1 g. portion of 1-(3-benzoylpropyl)-4-(3 -methyl-5-isoxazolyl)pyridinium perchlorate [prepared by the reaction of γ-chlorobutyrophenone and 4-(3-methyl-5-isoxazolyl)pyridine as described in the previous examples] in 200 ml. of methanol is added, portionwise with stirring, 4.1 g. of sodium borohydride. The mixture is allowed to stand at room temperature overnight, evaporated to about one-half volume and poured into ice water. The white solid is collected and recrystallized from acetonitrile, m.p. 108°-109° C.

Provenance & Evidence