Nitric Acid → 2-(Methylsulfinyl)-6-nitrobenzo[d]thiazole

Participants

Reaction Steps

At a temperature of 0° to 15° C, a mixture of 17.6 grams of fuming nitric acid and 35 grams of concentrated sulfuric acid was added dropwise while stirring to a solution of 18.1 grams (0.1 mole) of 2-methylmercaptobenzthiazole in 70 ml of concentrated sulfuric acid. The mixture was heated to 30°-35° C and stirred for a further 3 hours at this temperature. The reaction mixture was then poured onto 200 grams of ice, the 2-methylsulfinyl-6-nitrobenzthiazole was filtered off, washed until neutral and dried. 17.5 Grams of crude product were obtained (72.4 %).

Provenance & Evidence