Water → HCID 2755822, compound

Participants

Reaction Steps

5-Chloro-2-hydroxybenzaldehyde (15.6 g.) and n-butylamine (9.12 g) were refluxed in dry benzene (125 ml.) using Dean-Stark water separator for 3 hours. The benzene phase was concentrated to get the oily intermediate (23 g.). It was refluxed in glacial acetic acid (70 ml.) along with nitromethane (23 ml.) for 1 hour. The crude product was obtained by adding ice-water into the reaction mixture. The crude product was crystallised from benzene. The title product melted at 163-5° C.

Provenance & Evidence