Hydrochloric Acid → HCID 21506230, compound

Participants

Reaction Steps

A mixture of 54.8 g. (0.167 moles) of the ethyl α-chloro-β-(3-chloro-4-cyclohexylphenyl)propionate and 160 ml. of glacial acetic acid containing 40 ml. of 37% hydrochloric acid is refluxed for 20 hours. The mixture is concentrated under reduced pressure to give a gummy residue. The latter material is dissolved in 300 ml. of n-hexane, washed with ice-cold water (100 ml. total), dried over sodium sulfate and filtered. The hexane is removed to give α-chloro-β-(3-chloro-4-cyclohexylphenyl)propionic acid.

Provenance & Evidence