反应详情

A 9.1 g (0.04 mol) portion of 3'-hydroxy-2-methylbenzanilide was dissolved in a solution of 2.3 g (0.041 mol) of potassium hydroxide in 50 ml of ethanol, and 5.1 g (0.04 mol) of benzylchloride was added dropwise to the above solution with stirring at room temperature. After the addition, the reaction mixture was warmed and refluxed for 3 hours. The reaction mixture was poured into 200 ml of water and the precipitated product was filtered and washed with water and dried. The product was recrystallized from 90% methanol to obtain 7.5 g (60.5%) of white needles having a melting point of 114°-115° C.

1. additionwas added dropwise to the above solution
2. additionAfter the addition
3. temperaturethe reaction mixture was warmed
4. temperaturerefluxed for 3 hours
5. filtrationthe precipitated product was filtered
6. washwashed with water
7. customdried
8. customThe product was recrystallized from 90% methanol