Methanol → HCID 54045171, compound

Participants

Reaction Steps

In a Parr bomb, 2 g. of the compound of Example 1 is heated for 7 hours at 80°-90° C. with 2 g. of methyl isocyanate and 6 ml. of pyridine. After cooling, the reaction mixture is boiled in methanol for 5 minutes and the solvent is distilled off. The crude residue is triturated with acidic water, and after decantation is dissolved in anhydrous ethyl ether. Concentration of the ether solution gives a product that after crystallization from diisopropyl ether melts at 128°-131° C. Yield 2 g.

Provenance & Evidence