Phosphorus tribromide → HCID 12241060, compound

HRID 1287704Notes

Reaction equation

HRID 1287704 reaction equation
[C:1]([O:4][CH2:5][C:6]1[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][C:7]=1[CH:8](O)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)(=[O:3])[CH3:2].P(Br)(Br)[Br:22]>C(OCC)C>[C:1]([O:4][CH2:5][C:6]1[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][C:7]=1[CH:8]([Br:22])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 24614Phosphorus tribromideHCID 12241059HCID 12241059, compound

Product 1

HCID 12241060HCID 12241060, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

To a solution of 45 g. of 2-acetoxymethyl-5-chloro-benzhydrol in 270 ml. of ethyl ether, 13.7 g. of phosphorus tribromide in 45 ml. ethyl ether is added and the solution is stirred for 3 hours at room temperature. The organic solution is successively washed with a sodium bicarbonate solution and with water. After drying over sodium sulfate and evaporation of the solvent, 43.1 grams of the crude title compound is obtained which may be used for further reaction steps. B.p. 175°-180° C. 0.5 mm Hg.

Workup

  1. washThe organic solution is successively washed with a sodium bicarbonate solution and with water
  2. dry with materialAfter drying over sodium sulfate and evaporation of the solvent

Sources & evidence

ORD record
ord-86929346775741c4bce4cc3dadc50883
Source dataset
uspto-grants-1976_10
Patent number
US03985811

Reaction notes

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