HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1287719Generated: October 26, 2026
3-Chlorophenol → 4-(m-Chlorophenoxy)-3-nitro-5-sulphamyl-benzoic acid
https://huagongshe.com/reaction/1287719
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Chlorophenol | HCID 7933 | — |
| Reactant | 4-Chloro-3-nitro-5-sulphamoylbenzoic acid | HCID 89893 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-(m-Chlorophenoxy)-3-nitro-5-sulphamyl-benzoic acid | HCID 21506084 | — |
Reaction Steps
A mixture of 4-chloro-3-nitro-5-sulphamyl-benzoic acid (28 g), m-chlorophenol (26 g), sodium bicarbonate (34 g), and water (200 ml) was stirred at 85° C for 10 hours. After cooling, excess m-chlorophenol was removed by extraction with diethyl ether, and 4-(m-chlorophenoxy)-3-nitro-5-sulphamyl-benzoic acid was precipitated from the aqueous layer by the addition of 4N hydrochloric acid. After recrystallization from aqueous methanol, the melting point was 230°-232° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US03985777 |
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| Source dataset | uspto-grants-1976_10 |
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| ORD ID | ord-f01d4eb8a4fd4672a1b9c53223896397 |
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| Source note | uspto-grants-1976_10 |
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