Ammonia → 3-Nitro-4-phenoxy-5-sulphamyl-benzamide

HRID 1287764Notes

Reaction equation

HRID 1287764 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH:10]=[C:11]([S:20](=[O:23])(=[O:22])[NH2:21])[C:12]=1[O:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:7](Cl)=[O:8])([O-:3])=[O:2].[NH3:24]>>[N+:1]([C:4]1[CH:5]=[C:6]([CH:10]=[C:11]([S:20](=[O:23])(=[O:22])[NH2:21])[C:12]=1[O:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:7]([NH2:24])=[O:8])([O-:3])=[O:2]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 215060353-Nitro-4-phenoxy-5-sulfamoylbenzoyl chloride

Product 1

HCID 215060723-Nitro-4-phenoxy-5-sulphamyl-benzamide

Procedure

3-Nitro-4-phenoxy-5-sulphamyl-benzoyl chloride (4 g) was added in portions to liquid ammonia (40 ml). Then excess of ammonia was distilled off, and the residue was triturated with water (50 ml). The precipitated 3-nitro-4-phenoxy-5-sulphamyl-benzamide was isolated by filtration and recrystallized twice from aqueous ethanol. After drying in vacuo, the compound was obtained with a melting point of 255°-256° C.

Workup

  1. distillationThen excess of ammonia was distilled off
  2. customthe residue was triturated with water (50 ml)

Sources & evidence

ORD record
ord-d0ea5c23c35743649b8494542e3ada0e
Source dataset
uspto-grants-1976_10
Patent number
US03985777

Reaction notes

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