HCID 21506092, compound → HCID 21506141, compound

HRID 1287775Notes

Reaction equation

HRID 1287775 reaction equation
C([O:3][C:4](=[O:30])[C:5]1[CH:10]=[C:9]([S:11](=[O:14])(=[O:13])[NH2:12])[C:8]([NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[C:7]([NH:22][CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:6]=1)C>[OH-].[Na+]>[NH:15]([C:8]1[C:9]([S:11](=[O:14])(=[O:13])[NH2:12])=[CH:10][C:5]([C:4]([OH:30])=[O:3])=[CH:6][C:7]=1[NH:22][CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1

Participants

3

Reactant 1

HCID 21506092HCID 21506092, compound

Product 1

HCID 21506141HCID 21506141, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

A solution of ethyl-4-anilino-3-benzylamino-5-sulphamyl-benzoate (1 g) in 1N sodium hydroxide (15 ml) was heated on a steam bath for 1 hour. After cooling, the 4-anilino-3-benzylamino-5-sulphamyl-benzoic acid was precipitated by addition of acetic acid, collected and recrystallized from 60% ethanol in water. The melting point was 248°-249° C.

Workup

  1. temperatureAfter cooling
  2. customthe 4-anilino-3-benzylamino-5-sulphamyl-benzoic acid was precipitated by addition of acetic acid
  3. customcollected
  4. customrecrystallized from 60% ethanol in water

Sources & evidence

ORD record
ord-1808909e467f46c9a399ae1ce354d14e
Source dataset
uspto-grants-1976_10
Patent number
US03985777

Reaction notes

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