Propargyl bromide → HCID 21506135, compound

HRID 1287782Notes

Reaction equation

HRID 1287782 reaction equation
[CH2:1](Br)[C:2]#C.[CH2:5]([NH:8][C:9]1[CH:10]=[C:11]([CH:15]=[C:16]([S:25](=[O:28])(=[O:27])[NH2:26])[C:17]=1[O:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[C:12]([OH:14])=[O:13])[CH:6]=[CH2:7]>>[CH2:1]([O:13][C:12](=[O:14])[C:11]1[CH:15]=[C:16]([S:25](=[O:28])(=[O:27])[NH2:26])[C:17]([O:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[C:9]([NH:8][CH2:5][C:6]#[CH:7])[CH:10]=1)[CH3:2]

Participants

3

Reactant 2

HCID 7842Propargyl bromideHCID 21506049HCID 21506049, compound

Product 1

HCID 21506135HCID 21506135, compound

Procedure

By substituting propargyl bromide (4.8 g) for the allyl bromide of Example 58 A and extending the reaction time to 48 hours, ethyl-4-phenoxy-3-propargylamino-5-sulphamyl-benzoate was obtained with a melting point of 189°-190° C.

Workup

  1. customto 48 hours

Sources & evidence

ORD record
ord-95030440723746e99c9061448a13f847
Source dataset
uspto-grants-1976_10
Patent number
US03985777

Reaction notes

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