HCID 21506108, compound → 4-Phenoxy-3-(propylamino)-5-sulfamoylbenzoic acid

HRID 1287785Notes

Reaction equation

HRID 1287785 reaction equation
C([O:3][C:4](=[O:26])[C:5]1[CH:10]=[C:9]([S:11](=[O:14])(=[O:13])[NH2:12])[C:8]([O:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[C:7]([NH:22][CH2:23][CH2:24][CH3:25])[CH:6]=1)C>[OH-].[Na+]>[O:15]([C:8]1[C:9]([S:11](=[O:14])(=[O:13])[NH2:12])=[CH:10][C:5]([C:4]([OH:26])=[O:3])=[CH:6][C:7]=1[NH:22][CH2:23][CH2:24][CH3:25])[C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1

Participants

3

Reactant 1

HCID 21506108HCID 21506108, compound

Product 1

HCID 215060784-Phenoxy-3-(propylamino)-5-sulfamoylbenzoic acid

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

Ethyl-4-phenoxy-3-n-propylamino-5-sulphamyl-benzoate (1 g) was dissolved in 1N sodium hydroxide (15 ml), and heated on a steam bath for 1 hour. After cooling, the 4-phenoxy-3-n-propylamino-5-sulphamyl-benzoic acid was precipitated by addition of 4N hydrochloric acid until the pH was 2.5; the melting point was 223°-224° C.

Workup

  1. temperatureheated on a steam bath for 1 hour
  2. temperatureAfter cooling
  3. customthe 4-phenoxy-3-n-propylamino-5-sulphamyl-benzoic acid was precipitated by addition of 4N hydrochloric acid until the pH was 2.5

Sources & evidence

ORD record
ord-d30abcbb11b8434c8be00946d6e5ce8b
Source dataset
uspto-grants-1976_10
Patent number
US03985777

Reaction notes

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