Sodium Hydroxide → HCID 21506070, compound

Participants

Reaction Steps

A suspension of 4-butylamino-3-nitro-5-sulphamyl-benzoic acid (8.6 g) in water (175 ml) was adjusted to pH 9.5 by addition of 2N sodium hydroxide. The resulting solution was hydrogenated after additon of Pd-on-carbon catalyst (0.5 g catalyst containing 10% Pd). After the hydrogen uptake had become negligible, the catalyst was removed by filtration, and the 3-amino-4-butylamino-5-sulphamyl-benzoic acid was precipitated from the filtrate by addition of 4N hyrochloric acid until pH 3. After recrystallization from aqueous methanol the melting point was 211°-211.5° C.

Provenance & Evidence