反应详情

Ethyl 3-benzylamino-5-methylsulphamyl-4-phenoxy-benzoate (0.5 g) was dissolved in 1N sodium hydroxide (8 ml) and heated on a steam bath for 1 hour. After cooling, the 3-benzylamino-5-methylsulphamyl-4-phenoxy-benzoic acid was precipitated by addition of 4N hydrochloric acid until a pH of 2.5. The precipitate was collected by suction and recrystallized from aqueous ethanol. After drying in vacuo, the melting point of the compound was 231°-233° C.

1. temperatureheated on a steam bath for 1 hour
2. temperatureAfter cooling
3. customthe 3-benzylamino-5-methylsulphamyl-4-phenoxy-benzoic acid was precipitated by addition of 4N hydrochloric acid until a pH of 2.5
4. customThe precipitate was collected by suction
5. customrecrystallized from aqueous ethanol
6. customAfter drying in vacuo
7. customwas 231°-233° C.