Phosphoric Acid → HCID 88841109, compound

Participants

Reaction Steps

To a stirred solution of 9.3 g. (0.034 moles) of 7-aminocephalosporanic acid and 5.75 g. (0.068 moles) of sodium bicarbonate in 204 ml. of aqueous phosphate buffer at pH 6.4 was added 5.44 g. (0.034 moles) of 5-methylthiazole-2-thiocarboxylic acid. The mixture was stirred in a nitrogen atmosphere at 50° for 5 hours keeping the pH at 6.5 with 42% phosphoric acid. Then the mixture was cooled to 20° and the precipitated solid was removed by filtration, washed with water, acetone and ether and dried in vacuo over phosphorus pentoxide to provide 4.4 g. (35% yield) of a tan crystalline solid. Infrared and NMR spectra were consistent with the structure.

Provenance & Evidence